230000001575 pathological Effects 0.000 claims abstract description 6.201000009910 diseases by infectious agent Diseases 0.000 claims abstract description 6.206010053643 Neurodegenerative disease Diseases 0.000 claims abstract description 8.230000037361 pathway Effects 0.000 claims abstract description 9.230000002401 inhibitory effect Effects 0.000 claims abstract description 11.230000004481 post-translational protein modification Effects 0.000 claims abstract description 14.230000004913 activation Effects 0.000 claims abstract description 14.201000011510 cancer Diseases 0.000 claims abstract description 16.201000010099 disease Diseases 0.000 claims abstract description 24.229920000160 (ribonucleotides)n+m Polymers 0.000 claims abstract description 27.230000000865 phosphorylative Effects 0.000 claims abstract description 41.238000006366 phosphorylation reaction Methods 0.000 claims abstract description 41.238000006011 modification reaction Methods 0.000 claims abstract description 63.230000004048 modification Effects 0.000 claims abstract description 63.150000001413 amino acids Chemical class 0.000 claims abstract description 588.108020004707 nucleic acids Proteins 0.000 title description 33.239000000203 mixture Substances 0.000 title claims description 47.150000007523 nucleic acids Chemical class 0.000 title claims description 56.Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) Filing date Publication date Priority claimed from US201762576052P external-priority Application filed by The Broad Institute, Inc., Massachusetts Institute Of Technology, President And Fellows Of Harvard College filed Critical The Broad Institute, Inc. Massachusetts Institute Of Technology President And Fellows Of Harvard College Priority date (The priority date is an assumption and is not a legal conclusion. Inventor Feng Zhang Mohammad PIRMORADIAN NAJAFABADI Qiang PAN-HAMMARSTRÖM Jonathan Gootenberg David Benjamin Turitz Cox Omar Abudayyeh Original Assignee The Broad Institute, Inc. Google Patents Systems, methods, and compositions for targeted nucleic acid editing Google Patents WO2019084063A1 - Systems, methods, and compositions for targeted nucleic acid editing WO2019084063A1 - Systems, methods, and compositions for targeted nucleic acid editing

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